Genomic Insights into Multidrug and Extensively Drug-Resistant Klebsiella Pneumoniae from Bloodstream Infections at Three Zambian tertiary Hospitals

Abstract

Klebsiella pneumoniae is a leading cause of hospital-associated infections and a major contributor to antimicrobial resistance (AMR) worldwide. Despite its importance and prioritization in Zambia’s National Action Plan on AMR, genomic surveillance information in sub-Saharan Africa remains limited. This study investigated the population structure, determinants of AMR, and plasmid diversity of K. pneumoniae isolates from three tertiary hospitals in Zambia.